Product Description: EGTA is a specific calcium ion chelator. EGTA has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca2+ over Mg2+ (Mg2+ Kd 1-10 mM). EGTA significantly inhibits the substrate adherence capacity of inflammatory macrophages[1][2].
Formula: C14H24N2O10
References: [1]Harris RA, Hanrahan JW. Effects of EGTA on calcium signaling in airway epithelial cells. Am J Physiol. 1994;267(5 Pt 1):C1426-C1434. doi:10.1152/ajpcell.1994.267.5.C1426/[2]Segura-Egea JJ, Jiménez-Rubio A, Rios-Santos JV, Velasco-Ortega E, Calvo-Gutierrez JR. In vitro inhibitory effect of EGTA on macrophage adhesion: endodontic implications. J Endod. 2003;29(3):211-213.
CAS Number: 67-42-5
Molecular Weight: 380.35
Compound Purity: 98.0
Research Area: Inflammation/Immunology
Solubility: DMSO : 1 mg/mL (ultrasonic)/H2O : 5 mg/mL (ultrasonic;warming;adjust pH to 9 with NaOH;heat to 60°C)
Target: Biochemical Assay Reagents
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