Product Description: Fibrinogen (Bovine) is a selective proteolytic molecule that can be activated by thrombin to assemble fibrin clots. Fibrinogen can regulate the activation of NF-KB in endothelial cells and upregulate the expression of inflammatory chemokines MCP-1 and MCP-1. Fibrinogen plays a key role in blood clotting, thrombosis, atherosclerosis and the pathological development of venous grafts, and can be used in the study of blood clotting and vascular diseases[1][2][3].
Formula: N/A
References: [1]Guo M, et al. Fibrinogen regulates the expression of inflammatory chemokines through NF-kappaB activation of endothelial cells. Thromb Haemost. 2004;92(4):858-866./[2]Tyagi N, et al.Fibrinogen induces endothelial cell permeability. Mol Cell Biochem. 2008 Jan;307(1-2):13-22./[3]Brown JH, et al. The crystal structure of modified bovine fibrinogen. Proc Natl Acad Sci U S A. 2000;97(1):85-90.
CAS Number: 9001-32-5
Molecular Weight: N/A
Compound Purity: 92.0
Research Area: Inflammation/Immunology
Solubility: H2O : < 0.1 mg/mL (ultrasonic)
Target: Interleukin Related;NF-κB
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