Product Description: m-PEG-OH (MW 20000) can be used as a macroinitiator to participate in the synthesis of amphiphilic block copolymers. Nanoscale micelles can be prepared by using amphiphilic block copolymers to deliver active drugs. Paclitaxel (HY-B0015), a hydrophobic anticancer agent encapsulated in micelles, has stronger activity in killing cancer cells than free Paclitaxel. And it preferentially accumulates in tumor tissue with only limited distribution in healthy organs.
Applications: Cancer-programmed cell death
Formula: N/A
References: [1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562/[2]Lee AL, et al. The use of cholesterol-containing biodegradable block copolymers to exploit hydrophobic interactions for the delivery of anticancer drugs. Biomaterials. 2012 Feb;33(6):1921-8.
CAS Number: 9004-74-4
Molecular Weight: 20000(Average)
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: PROTAC Linkers
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