Product Description: Nε-(Carboxymethyl)-L-lysine (CML) is a unique post-translational modification (PTM) of proteins that is generated by the non-enzymatic glycation of lysine residues. Nε-(Carboxymethyl)-L-lysine is a relatively recently discovered modification, and has been found to be a major component of the advanced glycation endproducts (AGEs) found in multiple human diseases, such as diabetes, Alzheimer’s disease, and cancer[1].
Formula: C8H16N2O4
References: [1]Fu MX, et al. The advanced glycation end product, Nepsilon-(carboxymethyl)lysine, is a product of both lipid peroxidation and glycoxidation reactions. J Biol Chem. 1996 Apr 26;271(17):9982-6
CAS Number: 5746-04-3
Molecular Weight: 204.22
Research Area: Cancer; Metabolic Disease; Cardiovascular Disease
Solubility: 10 mM in DMSO
Target: Biochemical Assay Reagents
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