Formulation: Lyophilized from sterile 50 mM Tris, pH 7.4, with 150 mM NaCl, and 2 mM βME
Purity: ≥90% as determined by SDS-PAGE
Shelf life (days): 365
Notes: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped positive-stranded RNA virus and the causative agent of COVID-19, a primarily respiratory illness characterized by fever, cough, and shortness of breath that can lead to life-threatening complications.{53462,53459,53461,55257,55258} The SARS-CoV-2 genome contains approximately 30 kilobases and 14 open reading frames (ORFs) that encode four structural proteins: spike, envelope, membrane, and nucleocapsid, as well as 16 non-structural proteins and 9 accessory factors.{57176} SARS-CoV-2 non-structural protein 9 (nsp9) is an RNA binding protein. In the related virus SARS-CoV, nsp9 is highly conserved and important for RNA binding and viral replication.{52797} SARS-CoV-2 nsp9, like the nsp9 of SARS-CoV, forms dimers and contains a unique fold region not found in other CoVs. Cayman’s SARS-CoV-2 nsp9 protein consists of 140 amino acids and has a calculated molecular weight of 15.5 kDa.
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