Formulation: A solid
Formal Name: 3-(3,4-dimethoxyphenyl)-2-propenoic acid
Purity: ≥98%
Formula Markup: C11H12O4
Formula Weight: 208,2
Shelf life (days): 1460
CAS Number: 2316-26-9
Notes: Caffeic acid dimethyl ether is an ester-derivative of dihydrocaffeic acid (Item No. 27390) that has been found in C. arabica and has antifibrotic activities.{72297} It inhibits TGF-β1-induced cell growth in LX-2 hepatic stellate cells when used at a concentration of 20 µM. Caffeic acid dimethyl ether prevents TGF-β1-induced increases in the levels of collagen I, reactive oxygen species (ROS), and NADPH oxidase 4 (NOX4) in LX-2 cells. In vivo, caffeic acid dimethyl ether (20 mg/kg per day) reduces the serum levels of hyaluronic acid, laminin, procollagen type III, and collagen type IV and the liver levels of hydroxyproline in an ethanol- and carbon tetrachloride-induced rat model of hepatic fibrosis.
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