Formulation: A solid
Formal Name: chondroitin, hydrogen sulfate, monosodium salt
Formula Markup: C14H22NO15S • Na
CAS Number: 9082-07-9
Notes: Chondroitin sulfate A (CSA) is a glycosaminoglycan.{52864} It can be biosynthetically polymerized in a variety of species and serve as structural components in cartilage when tethered to extracellular proteins. CSA (0.5 or 1 mg/ml) reduces LPS-induced decreases in viability, as well as LPS-induced increases in Tnf-α, Il-1β, Il-6, Ifn-γ, inducible nitric oxide synthase (iNOS), and matrix metalloproteinase-1 (Mmp-1) levels, nitric oxide (NO) production, and NF-κB activity in primary mouse chondrocytes.{67738} Extracellular CSA is required for P. falciparum-infected erythrocytes to adhere to the endothelium in the brain and placenta and avoid immune detection.{67739} In vivo, CSA (30, 60, or 120 mg/kg per day) reduces arthritis incidence and joint swelling, decreases 8-isoprostane levels in articular cartilage cells, and increases IκBα levels in cartilage cell cytoplasm in a mouse model of collagen-induced arthritis.{67740}
English
Deutsch
