Formulation: A solid
Formal Name: 2-amino-2-deoxy-D-glucose-6 (dihydrogen phosphate), hydrate
Purity: ≥95%
Formula Markup: C6H14NO8P • XH2O
Formula Weight: 259,2
Shelf life (days): 1460
Notes: D-Glucosamine-6-phosphate (D-GlcN-6-P) is a monosaccharide intermediate of the hexosamine biosynthetic pathway.{59019} It is formed from D-fructose-6-phosphate by glucosamine-6-phosphate synthase (GlmS) in the presence of glutamine or from D-glucosamine (Item No. 27055) by N-acetyl-D-glucosamine (GlcNAc) kinase.{59020,59021,59022} D-GlcN-6-P binds the GlmS riboswitch (Ki = 380 µM), a ribozyme located in the 5'-UTR of the gene encoding GlmS that, when bound by D-GlcN-6-P, inhibits GlmS production and decreases D-GlcN-6-P levels.{59021,59023} It is a precursor in the biosynthesis of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc), a substrate for protein glycosylation and a component of bacterial cell walls.{59022,59024}
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