Formulation: A crystalline solid
Formal Name: 4-O-β-D-galactopyranosyl-D-gluconic acid, 4-O-β-D-galactopyranosyl-D-gluconic acid, δ-lactone
Purity: ≥95% (mixture of acid and lactone forms)
Formula Markup: C12H22O12 (for acid)
Formula Weight: 358,3
Shelf life (days): 1460
Notes: Lactobionic acid is an aldonic acid that is comprised of galactose and gluconic acid and can be produced by the lactose oxidation pathway in Pseudomonas.{31027,31029} Lactobionic acid increases the water solubility of clarithromycin and has been used as a low pH buffer for the entrapment of SYK kinase inhibitors in liposomal nanoparticles.{31031,31028} It also has antioxidant, humectant, and metal-chelating properties.{31027,31029} Topical administration of lactobionic acid (10% v/v) lowers the pH of the stratum corneum in mice.{31030} Formulations containing lactobionic acid have been used in cosmetic, pharmaceutical, biomedicine, and food applications as well as in the preservation of organs during transplantation.{31027,31029} The free acid and δ-lactone forms of lactobionic acid are interconvertible, with acidic pH conditions favoring formation of the δ-lactone form.{44020} Lactobionic acid is provided as a mixture of the free acid and lactone.
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