ARV-766, CAS 2750830-09-0

Formulation: A solid

Formal Name: 4-[4-[[1-[4-[[[trans-3-(4-cyano-3-methoxyphenoxy)-2,2,4,4-tetramethylcyclobutyl]amino]carbonyl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-N-[(3S)-2,6-dioxo-3-piperidinyl]-2-fluoro-benzamide

Purity: ≥98%

Formula Markup: C45H54FN7O6

Formula Weight: 808

Shelf life (days): 1460

CAS Number: 2750830-09-0

Notes: ARV-766 is a proteolysis-targeting chimera (PROTAC) that drives androgen receptor degradation.{69978} It induces degradation of the androgen receptor in VCaP cells with a half-maximal degradation concentration (DC50) value of less than 1 nM. ARV-766 inhibits tumor growth in various LNCaP and VCaP prostate cancer mouse xenograft models, including an enzalutamide-insensitive, non-castrated VCaP model.

• SKU: CAY41985-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41985-5
• Package Unit: 5 mg
• Quantity Unit: STK