ARV-825, CAS 1818885-28-7

Formulation: A crystalline solid

Formal Name: 2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethoxy)phenyl)acetamide

Purity: ≥98%

Formula Markup: C46H47ClN8O9S

Formula Weight: 923,4

Shelf life (days): 1460

CAS Number: 1818885-28-7

Notes: ARV-825 is a hetero-bifunctional molecule that is composed of a BRD4 binding moiety joined to an E3 ligase cereblon binding moiety using proteolysis targeting chimera (PROTAC) technology.{32899} ARV-825 actively recruits BRD4 to cereblon, resulting in the rapid and efficient degradation of BRD4 by the proteasome (50% maximum degradation at 14643), a competitor for binding to cereblon.{32966}

• SKU: CAY21109-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 21109-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK