Formulation: A crystalline solid
Formal Name: N-(4-azidobutyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-acetamide
Purity: ≥95%
Formula Markup: C19H20N6O6
Formula Weight: 428,4
Shelf life (days): 1460
CAS Number: 2098488-36-7
Notes: Azido-thalidomide is a building block in the synthesis of proteolysis-targeting chimera (PROTAC) technologies.{46112} It contains thalidomide, which is a ligand for the E3 ubiquitin ligase cereblon, and can be conjugated to alkynylated ligands for target proteins via click chemistry. Azido-thalidomide has been used in the synthesis of a SirReal-based PROTAC for the degradation of sirtuin 2 (Sirt2) in cells.