Formulation: A solid
Formal Name: N-[7-[(3R)-3-[[5-chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]-1-piperidinyl]heptyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-acetamide
Purity: ≥95%
Formula Markup: C40H49ClN8O8S
Formula Weight: 837,4
Shelf life (days): 1460
CAS Number: 2519823-34-6
Notes: BSJ-4-116 is a proteolysis-targeting chimera (PROTAC) composed of a modified form of the multi-kinase degrader TL12-186 linked to the cereblon ligand and PROTAC synthetic intermediate E3 ligase ligand 2 (Item No. 36664).{67542} It induces time- and concentration-dependent degradation of cyclin-dependent kinase 12 (Cdk12) in Jurkat T cells. BSJ-4-116 (50 nM) decreases expressions of various genes associated with DNA double-strand break repair in Jurkat cells. It inhibits the growth of MOLT-4 leukemia cells in a cereblon-dependent manner.
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