Product Description: C1s Enzyme is a subunit of the complement C1 complex, which activates the complement as a serine protease. C1s Enzyme cleaves LRP5 and LRP6, and thus activates the Wnt/β-Catenin signaling pathway. C1s Enzyme promotes the macrophage M2 polarization and inhibits M1 polarization. C1s Enzyme enhances efferocytosis, exhibits anti-inflammatory activity[1].
Formula: N/A
References: [1]Yuan D, et al. Cytoprotective effects of C1s enzyme in macrophages in atherosclerosis mediated through the LRP5 and Wnt/β-catenin pathway. Mol Immunol. 2024 Feb;166:29-38.
Molecular Weight: N/A
Research Area: Inflammation/Immunology; Cardiovascular Disease
Target: Wnt