Dth

Formulation: A solution in ethanol

Formal Name: (Z)-4-((6-(4-(3,5-difluoro-4-hydroxybenzylidene)-2-methyl-5-oxo-4,5-dihydro-1H-imidazol-1-yl)hexyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Purity: ≥95%

Formula Markup: C30H29F2N5O6

Formula Weight: 593,6

Shelf life (days): 730

Notes: Dth is a proteolysis-targeting chimera (PROTAC) composed of the fluorescent probe for RNA DFHBI (Item No. 34555) and the immunomodulatory compound thalidomide (Item No. 14610).{65933} It binds to a genetically expressed RNA aptamer comprising Broccoli and a modifiable and selective protein targeting sequence and induces degradation of mCherry in HEK293T cells when used at a concentration of 20 µM. Dth (20 µM) induces degradation of the NF-κB subunit p50, as well as p50 and the E2F transcription factor subtype E2F1, in MCF-7 cells.

• SKU: CAY38925-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 38925-5
• Package Unit: 5 mg
• Quantity Unit: STK