Formulation: Lyophilized from sterile 20 mM Tris, 300 mM sodium chloride, pH 7.5, with 10% glycerol, 5% trehalose, 5% mannitol, and 0.01% tween-80
Purity: ≥90% estimated by SDS-PAGE
Shelf life (days): 365
Notes: Cytosolic β-glucosidase (GBA3) is a neutral β-glucocerebrosidase.{60901,60902} It is composed of a single glycoside hydrolase domain and hydrolyzes glucosyl- and galactosylceramides. GBA3 is expressed in the liver, small intestine, colon, spleen, and kidneys.{60904} In vitro, knockdown of GBA3 inhibits mitotic arrest and promotes resistance to paclitaxel (Item No. 10461) in colon cancer cells.{60905} Tumor levels of GBA3 are lower in patients with hepatocellular carcinoma and decreased expression is associated with poor prognosis.{60906} Unlike GBA1, polymorphisms in GBA3 are not associated with Gaucher disease, a lysosomal storage disorder.{60953} Cayman’s GBA3 (human, recombinant) protein can be used for enzyme activity assays. This protein consists of 480 amino acids and has a calculated molecular weight of 55 kDa.
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