Formulation: 40 mM Tris-HCl, pH 8.0, 110 mM sodium chloride, with 2.2 mM potassium chloride, 0.04% Tween 20, 3 mM DTT, and 20% glycerol
Purity: ≥65% estimated by SDS-PAGE
Shelf life (days): 180
Notes: HDAC6 is a Class II HDAC that can shuttle between the nucleus and cytoplasm, suggesting potential extranuclear functions by regulating the acetylation status of non-histone substrates. By modifying chromatin structure and other non-histone proteins, HDACs play important roles in controlling complex biological events, including cell development, differentiation, programmed cell death, angiogenesis, and inflammation.{14467,14468} Considering these major roles, it is conceivable that dysregulation of HDACs and subsequent imbalance of acetylation and deacetylation may be involved in the pathogenesis of various diseases, including cancer and inflammatory diseases.{14467}
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