Purity: ≥56% estimated by SDS-PAGE
Shelf life (days): 180
Notes: Histone deacetylase 7 (HDAC7) is a zinc-dependent metalloenzyme and class IIa HDAC.{22864} It is composed of an N-terminal regulatory domain, which contains a myocyte-specific enhancer factor 2 (MEF2) binding site, three 14-3-3 binding sites, and a nuclear localization signal, a catalytic domain, and a C-terminal domain that contains a nuclear export signal.{22864} HDAC7 shuttles between the cytoplasm, mitochondria, and nucleus and is expressed in the heart, placenta, pancreas, lungs, and skeletal muscle.{66873,66874} It acts as a transcriptional corepressor and has many binding partners, including MEF2, nuclear receptor co-repressor (NCOR), and hypoxia-inducible factor-1α (HIF-1α), and its enzymatic activity is dependent on association with HDAC3.{22864,66873} HDAC7 is involved in immunity, angiogenesis, embryonic development, muscle cell differentiation, and apoptosis.{66875,26846,66874} Knockdown of HDAC7 inhibits sphere formation of breast cancer stem cells (CSCs) in vitro.{50444} Hdac7-/- is embryonic lethal and induces hemorrhages, pericardial effusion, and enlarged dorsal aortae in mice.{66876} Expression of HDAC7 is increased in patients with various cancers and is associated with poor prognosis.{66875} Cayman's HDAC7 (human, recombinant) protein can be used for enzyme activity assays.
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