HMG-CoA Reductase (human recombinant)

Formulation: 50 mM Tris, pH 8.0, with 300 mM sodium chloride and 20% glycerol

Purity: ≥85% estimated by SDS-PAGE

Shelf life (days): 730

Notes: HMG-CoA reductase (HMGR) is a highly regulated enzyme found on the endoplasmic reticulum (ER) membrane. It is bound to the ER membrane by a multi-pass 339 amino acid N-terminal transmembrane domain while the carboxy terminal catalytic region projects into the cytosol.{26861,26862} HMGR is controlled by feedback regulation from sterols and non-sterol metabolites derived from mevalonate.{26862,26863,26860} Binding of cholesterol derived from internalized LDL receptors suppresses HMGR. The enzyme is responsible for catalyzing the rate-limiting step in cholesterol biosynthesis. Mevalonate, which is converted to isopentenyl pyrophosphate, is the building block for cholesterol and non-sterol isoprenoids. The four-electron reduction of HMG-CoA catalyzed by HMGR to form mevalonate is the committed step in the biosynthesis of sterols and isoprenoids.{15309} Potent inhibitors of HMGR, collectively called statins, are effective in lowering mortality due to hypercholesterolemia by lowering serum cholesterol levels.{26864}

• SKU: CAY14944
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 14944-250
• Green Labware: No
• Package Unit: 250 µg
• Quantity Unit: STK