Formulation: 40 mM Tris-HCl, pH 8.0, 300 mM sodium chloride, 2.2 mM potassium chloride, 20% glycerol, and 0.2 mM TCEP
Purity: ≥90% estimated by SDS-PAGE
Formula Weight: 0
Shelf life (days): 180
Notes: JAK2 is a non-receptor tyrosine kinase that has roles in immune signaling.{19346,54923} It is composed of N-terminal FERM and SH2 domains, a regulatory JH2 pseudokinase domain, and a C-terminal JH1 kinase domain. It is widely expressed and associates with class I and class II cytokine receptors at the plasma membrane.{54921,54922} Activation of these cytokine receptors activates JAK2 and induces its dimerization and kinase activity, leading to JAK2 phosphorylation of STAT transcription factors and transcription of immune-related target genes. JAK2 signaling is inhibited by the suppressor of cytokine signaling (SOCS) proteins SOCS1 and SOCS3.{54924,54925} Gain-of-function mutations in JAK2, such as JAK2V617F in the JH2 domain, are associated with various blood disorders, including leukemias and myeloproliferative neoplasms.{54922} Cayman’s JAK2 JH2 Domain (human, recombinant; aa 513-827) - Biotinylated protein can be used for pull-down assays and has a calculated molecular weight of 39 kDa.
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