JMJD2D (human, recombinant)

Formulation: A solution in 50 mM HEPES, pH 7.4, with 150 mM sodium chloride and 20% glycerol

Purity: ≥75% estimated by SDS-PAGE

Shelf life (days): 180

Notes: Methylation of lysine residues in core histones plays a critical role in regulating gene expression.{18003} Jumonji domain containing 2D (JMJD2D) catalyzes the demethylation of di- and tri-methylated forms of histone H3 at lysine residue 9 (me 2/3), leading to transcriptional repression and activation, respectively.{18004} Like other JmjC protein hydroxylase family members, JMJD2D is an α-ketoglutarate-dependent Fe (II) oxygenase.{17970} Because of their implication in cancer cell growth, jumonji C domain-containing histone demethylase inhibitors may have the capacity to be anticancer agents.{18003}

• SKU: CAY10335
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 10335-100
• Green Labware: No
• Package Unit: 100 µg
• Quantity Unit: STK