Formulation: A solid
Formal Name: 5-(4-amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione-3,3,4,4,5-d5
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C13H8D5N3O3
Formula Weight: 264,3
Shelf life (days): 1460
CAS Number: 1227162-34-6
Notes: Lenalidomide-d5 is intended for use as an internal standard for the quantification of lenalidomide (Item No. 14643) by GC- or LC-MS. Lenalidomide is a derivative of the immunomodulatory compound thalidomide (Item No. 14610).{64871} It reduces TNF-α production in isolated human peripheral blood mononuclear cells (PBMCs) and whole blood stimulated by LPS from S. minnesota (Item No. 23608; IC50s = 13 and 25 nM, respectively). Lenalidomide has been used as a building block in the synthesis of PROTACs that induce the degradation of Ikaros family zinc finger protein 1 (IKZF1) and IKZF3 in MM.1S multiple myeloma cells.{64872} Orally administered lenalidomide (250 mg/kg per day) reduces vascularization and total microvascular length in a rat mesenteric window assay.{64873} Formulations containing lenalidomide have been used in the treatment of myelodysplastic syndrome and multiple myeloma.
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