Formulation: 100 mM Tris, pH 8.0, with 100 mM potassium chloride and 20% glycerol
Purity: ≥90% estimated by SDS-PAGE
Shelf life (days): 365
Notes: Leukotriene A4 hydrolase (LTA4H) is a bifunctional zinc metalloenzyme that converts LTA4 into LTB4, a potent neutrophil chemoattractant.{12673} In addition to the hydrolase activity, LTA4H also exhibits anion-dependent aminopeptidase activity.{12673,12624} LTA4H is a potential new drug target for a variety of indications associated with leukocyte infiltration to sites of inflammation. Cayman’s LTA4H (human, recombinant) has been expressed and purified from E. coli. Both the epoxide hydrolase and aminopeptidase activities of the enzyme are functional as assessed by measurement of the separate enzyme activities. The enzyme therefore has application for the screening of inhibitors of LTB4 synthesis.
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