Formulation: A solid
Formal Name: 2-[2-[2-[4-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]ethoxy]ethoxy]-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1, 3-dioxo-1H-isoindol-5-yl]-acetamide
Purity: ≥95%
Formula Markup: C41H41N9O8
CAS Number: 2231744-29-7
Notes: MT-802 is a proteolysis-targeting chimera (PROTAC) composed of the Bruton’s tyrosine kinase (BTK) inhibitor ibrutinib (Item No. 16274) linked to the cereblon inhibitor pomalidomide (Item No. 19877).{69672} It induces degradation of BTK in NAMALWA cells when used at concentrations ranging from 10 to 250 nM. MT-802 (1 µM) induces BTK degradation in primary X-linked agammaglobulinemia (XLA) cells expressing wild-type BTK or the ibrutinib-resistant mutant BTKC481S. It also induces BTK degradation in patient-derived chronic lymphocytic leukemia (CLL) cells.
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