Product Description: N-Acetylgalactosaminyltransferase 1 (GALNT1) is a glycosyltransferase that initiates mucin-type O-glycosylation by transferring α-GalNAc from UDP-GalNAc to serine (Ser) or threonine (Thr) residues in proteins. Overexpression of N-Acetylgalactosaminyltransferase 1 in gastric cancer promotes the Wnt/β-catenin signaling pathway through abnormal O-glycosylation of CD44, thereby enhancing malignancy. N-Acetylgalactosaminyltransferase 1 plays a crucial role in cancer growth and metastasis by modifying O-glycosylation of various glycoproteins, such as mucin (MUC1), osteopontin (OPN), matrix metalloproteinase-14 (MMP14), and integrin α3[1].
Formula: N/A
References: [1]Zhang J, et al. GALNT1 Enhances Malignant Phenotype of Gastric Cancer via Modulating CD44 Glycosylation to Activate the Wnt/β-catenin Signaling Pathway. Int J Biol Sci. 2022 Oct 17;18(16):6068-6083.
Molecular Weight: N/A
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: Endogenous Metabolite;Wnt;β-catenin
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