Nicotinamide N-Methyltransferase (human, recombinant)

Formulation: 50 mM Tris, pH 8.0, containing 500 mM sodium chloride, 5% glycerol, and 1 mM DTT

Purity: ≥95% estimated by SDS-PAGE

Shelf life (days): 180

Notes: Nicotinamide N-Methyltransferase (NNMT) methylates nicotinamide and other pyridine containing compounds.{24617} NNMT transfers a methyl group from S-adenosylmethionine (SAM) to nitrogen N1 of nicotinamide to produce 1-methylnicotinamide (MNA) and S-adenosylhomocysteine. MNA is a messenger molecule that increases neurite branching, serves as an anti-thrombotic, and has anti-inflammatory properties.{24616,24618,24614} The role of NNMT overexpression in cancers may be to alter epigenetic methylation patterns in two ways: by lowering the intracellular concentration of SAM, required by methyltransferase enzymes, and by depleting the available NAD+ by transforming nicotinamide to MNA.{24614,24772} Sirtuins use NAD+ as a substrate to alter protein acetylation and ribosylation, including histone targets.{24614}

• SKU: CAY15138
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 15138-100
• Green Labware: No
• Package Unit: 100 µg
• Quantity Unit: STK