Formulation: Lyophilized from sterile 20 mM Tris, 500 mM sodium chloride, pH 7.4, with 10% glycerol and 3 mM DTT
Purity: ≥85 % as determined by SDS-PAGE
Shelf life (days): 365
Notes: Phosphodiesterase 1C (PDE1C) is a calcium/calmodulin-dependent PDE that hydrolyzes cAMP and cGMP.{52567,52569} Alternative splicing of PDE1C produces three isoforms that exhibit isoform-specific tissue distribution and domain structure.{52567} PDE1C isoforms all contain a calcium/calmodulin binding region and a PDE catalytic domain but vary in carboxyterminal length.{52568} PDE1C1 is a 72 kDa isoform that is primarily expressed in the heart and brain but is also expressed in the lungs, uterus, and testes. PDE1C1 is expressed in MAA human malignant melanoma cells.{52571} Hippocampal PDE1C1 expression is increased in aged rats.{52570} Cayman’s PDE1C1 (human, recombinant) protein consists of 871 amino acids and has a calculated molecular weight of 100 kDa.
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