PROTAC CRBN Degrader-1, CAS 2358775-70-7

Formulation: A solid

Formal Name: N1-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethyl)-N20-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,9,12,18-tetraoxaicosanediamide

Purity: ≥95%

Formula Markup: C53H72N8O13S

Formula Weight: 1061,3

Shelf life (days): 1460

CAS Number: 2358775-70-7

Notes: PROTAC CRBN degrader-1 is a proteolysis-targeting chimera (PROTAC) that contains VHL ligand 1 (Item No. 21591) conjugated to the cereblon (CRBN) inhibitor pomalidomide (Item No. 19877).{68903} It induces degradation of CRBN in HeLa cells with a half-maximal degradation concentration (DC50) value of 200 nM.

• SKU: CAY41878-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41878-1
• Package Unit: 1 mg
• Quantity Unit: STK