PROTAC(H-PGDS)-7, CAS 2761281-50-7

Formulation: A crystalline solid

Formal Name: N-[4-[4-[[4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-1-piperazinyl]carbonyl]-1-piperidinyl]phenyl]-2-phenoxy-5-pyrimidinecarboxamide

Purity: ≥95%

Formula Markup: C40H38N8O7

Formula Weight: 742,8

Shelf life (days): 730

CAS Number: 2761281-50-7

Notes: PROTAC(H-PGDS)-7 is a proteolysis-targeting chimera (PROTAC) comprised of the hematopoietic prostaglandin D synthase (H-PGDS) inhibitor TFC-007 (Item No. 17971) and the cereblon inhibitor pomalidomide (Item No. 19877).{62523} It induces degradation of H-PGDS in KU812 cells with a 50% degradation concentration (DC50) value of 17.3 pM, as well as decreases the production of prostaglandin D2 (PGD2) in the same cells.

• SKU: CAY35561-500
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 35561-500
• Green Labware: No
• Package Unit: 500 µg
• Quantity Unit: STK
• Application: Reinstoffe