Formulation: 100 mM Tris, pH 7.2, with 100 mM sodium chloride, 1 mM EDTA, and 25% glycerol
Purity: ≥90% estimated by SDS-PAGE
Shelf life (days): 365
Notes: Protein tyrosine phosphatase (PTPs) are an enzyme superfamily that includes about 100 human proteins.{15395} Their function is to remove phosphate from tyrosine residues of cellular proteins.{15394} Reversible phosphorylation catalyzed by the coordinated actions of protein tyrosine kinases and phosphatases is of paramount importance to the regulation of the signaling events that underlie such fundamental processes as growth and proliferation, differentiation, and survival or apoptosis, as well as adhesion and motility.{15396} One of the most heavily studied PTP proteins is PTP1B. Data suggests PTP1B is a negative regulator in both insulin and leptin signaling.{15396} As such, PTP1B has become a leading diabetes drug target.{15395}
English
Deutsch
