Formulation: Lyophilized from sterile PBS, pH 7.4
Purity: ≥95% estimated by SDS-PAGE
Formula Weight: 0
Shelf life (days): 365
Notes: Prostate-specific membrane antigen (PSMA) is a type II membrane glycoprotein and glutamate-preferring carboxypeptidase with roles in folic acid utilization and metabolism that is encoded by FOLH1 in humans.{60113,60116} It is composed of a short intracellular sequence, a transmembrane domain, and a large extracellular region, which contains enzymatic domains.{60113,60114} PSMA is expressed in prostate epithelial cells and in the proximal small intestine, where it promotes folate uptake by cleaving glutamate from folypoly-γ-glutamate, and in the central nervous system, where it regulates neurotransmitter activity by cleaving glutamate from N-acetyl-aspartyl-glutamate (NAAG).{60116,60115} It is also highly overexpressed in prostate carcinomas and in the neovasculature of various renal, colon, and breast carcinomas to support the need for folate in these rapidly dividing cells.{60116,60115} Expression of FOLH1 increases under androgen deprivation conditions in vitro and in vivo and positively correlates with cancer aggressiveness in patients with prostate cancer.{60113} PSMA PET imaging is commonly used in the diagnosis and staging of prostate cancer, as well as to assess therapeutic response.{60114} Cayman's PSMA Extracellular Domain (human, recombinant) - Biotinylated protein consists of 732 amino acids and has a calculated molecular weight of 82.72 kDa. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is 99.7 kDa due to glycosylation.
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