Formulation: 50 mM Tris, pH 8.0, containing 150 mM sodium chloride and 20% glycerol
Purity: ≥90%
Shelf life (days): 180
Notes: Retinoblastoma-binding protein 5 (RbBP5) is a ubiquitously expressed nuclear protein that contains WD40 repeat-like domains. RbBP5 binds directly to tumor suppressor retinoblastoma protein (RB) and regulates cell proliferation. Interaction of RbBP5 occurs preferentially with underphosphorylated RB through the E1A-binding pocket B.{20225} RbBP5 is also an important component of the multi-subunit SET1 lysine methyltransferase protein complex, which includes MLL1.{19554} RbBP5 interacts directly with WDR5 contributing to the activation of the MLL1 core protein complex.{20250,19568,19551} MLL1-4 protein complexes catalyze the di- and trimethylation of histone H3 at lysine 4 (H3K4me2/me3), leading to the maintenance of global H3K4 trimethylation.{19556}
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