SET8 (human recombinant)

Formulation: 50 mM sodium phosphate, pH 7.2, with 100 mM sodium chloride and 20% glycerol

Purity: ≥90% estimated by SDS-PAGE

Shelf life (days): 180

Notes: Methylation of lysine can promote transcriptional activation or repression and is critical in regulating histone function. Lysine residues can be mono-, di-, or tri-methylated.{17798} SET8 selectively mono-methylates histone H4 at lysine 20, an event proven to have an important role in chromatin structure and transcriptional activation.{17452,17451} SET8 is also a novel regulator of p53, mono-methylating lysine 382 of the tumor suppressor.{17453} SET8’s ability to suppress p53 transcriptional activity implies that it may play a significant role in tumorigenesis.

• SKU: CAY10319
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 10319-100
• Green Labware: No
• Package Unit: 100 µg
• Quantity Unit: STK