Formulation: 25 mM Tris-HCl, pH 8.0, with 100mM NaCl, 20% glycerol
Purity: ≥80% estimated by SDS-PAGE
Shelf life (days): 545
Notes: The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group.{15271,15275,15273} There are seven human sirtuins, which have been designated SIRT1-7.{15274} SIRT6 associates specifically with telomeres and functions at chromatin to decrease NF-κB signaling.{17071,15626} Mammalian cells depleted of SIRT6 display abnormal telomere structures similar to defects found in Werner syndrome, a premature ageing disorder, and have a shortened life span.{17071,15626} Since SIRT6 binds and attenuates NF-κB signaling, it is proposed that activators of SIRT6 may be effective anti-cancer and anti-inflammatory drugs and may increase longevity.{17071}
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