Product Description: Thermolysin, Bacillus thermoproteolyticus rokko (EC 3.4.24.27) (TML) is a thermostable neutral metalloproteinase enzyme secreted by the Gram-positive bacteria Bacillus thermoproteolyticus. Thermolysin catalyzes the hydrolysis of peptide bonds containing hydrophobic residues[1].Optimal pH: 8.0. Considerably stable from pH 5 to 9.5.Optimal temperature : 70 °C
Applications: COVID-19-immunoregulation
Formula: N/A
References: [1]Bertusvan den Burg, et al. Chapter 111 - Thermolysin and Related Bacillus Metallopeptidases. /[2]Mu-Forster C, et al. Surface localization of zein storage proteins in starch granules from maize endosperm. Proteolytic removal by thermolysin and in vitro cross-linking of granule-associated polypeptides. Plant Physiol. 1998 Apr;116(4):1563-71. /[3]Di Bernardini R, et al. Isolation, purification and characterization of antioxidant peptidic fractions from a bovine liver sarcoplasmic protein thermolysin hydrolyzate. Peptides. 2011 Feb;32(2):388-400. /[4]Fujita H, et al: a prodrug-type ACE-inhibitory peptide derived from fish protein. Immunopharmacology. 1999 Oct 15;44(1-2):123-7. /[5]Ke Q, et al. Safety evaluation of a thermolysin enzyme produced from Geobacillus stearothermophilus. Food Chem Toxicol. 2013 Sep;59:541-8.
CAS Number: 9073-78-3
Molecular Weight: N/A
Research Area: Infection
Solubility: H2O : 1.96 mg/mL (adjust pH to 3 with HCl)
Target: Endogenous Metabolite
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