Toxin A from Clostridium difficile

Formulation: Each vial contains 100 µg of C. difficile toxin A enterotoxin; when reconsituted with 0.5 ml of water, the buffer contains 50 mM Tris, 50 mM NaCl, pH 7.5, and 0.1% trahalose

Purity: ≥80% (estimated by SDS-PAGE)

Shelf life (days): 730

Notes: Toxin A from Clostridium difficile, also known as TcdA, is an enterotoxin that has glucosyltransferase and cysteine protease activities. It inactivates host Rho family GTPases by glucosylation, altering cytoskeletal structure, cell division, and cell-cell adhesion.{31338,31340} Toxin A can induce activation of the inflammasome and apoptosis.{31339} While both toxin A and toxin B (Item No. 19665) inactivate Rho family GTPases, toxin A has a higher binding affinity for epithelial cell surface carbohydrates.{31340}

• SKU: CAY19664
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 19664-100
• Green Labware: No
• Package Unit: 100 µg
• Quantity Unit: STK