Toxin B from Clostridium difficile

Formulation: Each vial contains 50 μg of C. difficile toxin B in 50 mM Tris, 100 mM NaCl, pH 7.5, at a concentration of 0.2 mg/ml

Purity: ≥90% (estimated by SDS-PAGE)

Shelf life (days): 730

Notes: Toxin B from Clostridium difficile, also known as TcdB, is a cytotoxin that has glucosyltransferase and cysteine protease activities. It inactivates host Rho family GTPases by glucosylation, altering cytoskeletal structure, cell division, and cell-cell adhesion.{31338,31340} Toxin B can induce activation of the inflammasome and apoptosis.{31339} While both toxin A (Item No. 19664) and toxin B inactivate Rho family GTPases, toxin B more potently induces mammalian cell rounding in culture.{31340}

• SKU: CAY19665
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 19665-50
• Green Labware: No
• Package Unit: 50 µg
• Quantity Unit: STK