Formulation: A crystalline solid
Formal Name: cyano(6-methoxy-2-napthalenyl)methyl[(2,3)-3-phenyloxiranyl]methyl ester, carbonic acid
Purity: ≥98%
Formula Markup: C23H19NO5
Formula Weight: 389,4
Shelf life (days): 365
CAS Number: 863223-43-2
Notes: Soluble epoxide hydrolase (sEH) catalyzes the conversion of epoxyeicosatrienoic acids (EpETrEs) to the corresponding DiHETrEs thereby diminishing their vasodilator activity.{12607} Inhibitors of sEH may therefore have clinical utility for treating hypertension and systemic inflammation.{14065,14072} Epoxy fluor 7 is a sensitive fluorescent substrate for soluble epoxide hydrolase (sEH) that can be used to monitor the activity of both human and mouse enzymes.{14078} Hydrolysis of the substrate epoxide yields a highly fluorescent product that can be monitored at excitation and emission wavelengths of 330 and 465 nm, respectively. Epoxy fluor 7 is more stable in aqueous solution and offers about 2-fold better sensitivity than previously used colorimetric substrates such as NEPC.{14078}
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