Formulation: A solid
Formal Name: 2-[[[2-(4-ethylphenyl)-5-methyl-4-oxazolyl]methyl]thio]-N-(2-phenylethyl)-acetamide
Purity: ≥95%
Formula Markup: C23H26N2O2S
Formula Weight: 394,5
Shelf life (days): 1460
CAS Number: 901751-47-1
Notes: iCRT3 is an inhibitor of β-catenin-responsive transcription (CRT).{39368} It inhibits Wnt signaling in a reporter assay using HEK293 cells (IC50 = 8.2 nM). It is selective for inhibition of the protein-protein interaction between β-catenin and T cell factor (Tcf) over the interaction between β-catenin and epithelial cadherin (E-cadherin) or α-catenin. iCRT3 (50 µM) inhibits neurotensin- or Wnt3a-induced increases in the proliferation of A172 and U87 glioblastoma cells.{51779} It also reduces tumor growth in an A172 mouse xenograft model when administered at a dose of 5 mg/kg. iCRT3 (5 and 10 mg/kg) reduces plasma levels of IL-6, TNF-α, and IL-1β, as well as the general organ damage marker aspartate aminotransferase (AST) and the liver damage marker alanine transaminase (ALT) in a mouse model of cecal ligation and puncture-induced sepsis.{51780} It also reduces lung cell apoptosis and the severity of sepsis-induced lung injury in the same model when administered at a dose of 10 mg/kg.
English
Deutsch
