Formulation: A solution in ethanol
Formal Name: 12S-hydroxy-5Z,8E,10E-heptadecatrienoic acid
Purity: ≥95%
Formula Markup: C17H28O3
Formula Weight: 280,4
Shelf life (days): 365
CAS Number: 54397-84-1
Notes: 12(S)-HHTrE is a product of the cyclooxygenase (COX) pathway and one of the primary arachidonic acid metabolites of human platelets.{567} It is biosynthesized by thromboxane (TXA2) synthase from prostaglandin H2 (PGH2) concurrently with TXA2. 12(S)-HHTrE is a natural lipid agonist of the leukotriene B2 receptor BLT2 in vivo that induces chemotaxis of mast cells and accelerates wound closure.{15587,26266} 12(S)-HHTrE is avidly oxidized to 12-oxoHTrE by porcine 15-hydroxy PGDH.{566}