Formulation: A solution in ethanol
Formal Name: 15R-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid
Purity: ≥98%
Formula Markup: C20H32O3
Formula Weight: 320,5
Shelf life (days): 730
CAS Number: 83603-31-0
Notes: 15(R)-HETE is a monohydroxy fatty acid. It is produced by aspirin-acetylated COX-2 from arachidonic acid (Item Nos. 90010 / 90010.1 / 10006607) and converted into the specialized pro-resolving mediator 15(R)-lipoxin A4 (Item No. 90415) and 15(R)-lipoxin B4 in a transcellular process via 5-lipoxygenase (5-LO).{1504,1506,8116,2629,369} It is also produced by the cytochrome P450 (CYP) isoform CYP2C9.{1504,1506,8116,65098} 15(R)-HETE can also be formed from arachidonic acid by COX-1 in stimulated human mast cells and accumulates because, unlike 15(S)-HETE (Item No. 34720), it is not converted to 15-KETE (15-OxoETE; Item No. 34730) by 15-hydroxyprostaglandin dehydrogenase (15-PGDH).{55556} It is an agonist of PPARβ/δ, inducing expression of a PPARβ/δ target gene in a reporter assay using NIH3T3 cells.{65099}
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