2-Arachidonyl Glycerol ether, CAS 222723-55-9

Formulation: A solution in ethanol

Formal Name: 5Z,8Z,11Z,14Z-eicosatetraen-2-glyceryl ether

Purity: ≥98%

Formula Markup: C23H40O3

Formula Weight: 364,6

Shelf life (days): 180

CAS Number: 222723-55-9

Notes: 2-Arachidonyl glycerol ether (2-AG ether) selectively binds to cannabinoid (CB) receptor 1 (Kis = 21.2 and >3,000 nM for CB1 and CB2, respectively, in a radioligand binding assay).{8945} It is a potent and selective agonist of CB1 and GPR55 with EC50 values of 10, 37, and >30,000 nM for CB1, GPR55, and CB2, respectively.{17583} 2-AG ether displays the typical tetrad of CB activities in mice.{8945} It is more chemically stable than 2-AG (Item No. 62160), with an endogenous half-life of hours rather than minutes.{10462} However, it is at least 10-fold less potent than 2-AG in eliciting typical CB1-mediated responses.{7182} 2-AG ether elicits modest reductions in intraocular pressure in rabbits when administered at doses exceeding 50 µg per eye.{10462} It increases aqueous humor outflow via the CB1 receptor in the trabecular meshwork.{14129} Administration of 2-AG ether to the nucleus accumbens (0.0625-1 μg) increases dietary intake and enhances fat consumption in rats given access to both high-carbohydrate and high-fat diets.{38343}

• SKU: CAY62165-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 62165-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK