Formulation: A solution in water
Formal Name: 2-chloro-adenosine 5′-(tetrahydrogen triphosphate), tetrasodium salt
Purity: ≥95%
Formula Markup: C10H11ClN5O13P3 • 4Na
Formula Weight: 629,6
Shelf life (days): 730
CAS Number: 301334-89-4
Notes: 2-Chloroadenosine 5-triphosphate (2-chloro ATP) is an adenine nucleotide and analog of ATP (Item No. 14498).{62566,62567} It is an antagonist of the purinergic P2Y1 receptor, inhibiting intracellular calcium mobilization induced by ADP (Item No. 21121) in Jurkat cells expressing the human receptor (Ki = 2.3 µM).{62568} 2-chloro ATP is an agonist of purinergic P2X receptors, inducing inward currents in HEK293 cells expressing the human bladder smooth muscle or rat PC12 forms of the receptor (EC50s = 0.5 and 2.5 µM, respectively).{62569} It induces relaxation of precontracted isolated guinea pig taenia caeci strips in a concentration-dependent manner.{62566} It has been used to study the substrate specificity of cyclic nucleotide-dependent protein kinases, such as protein kinase A (PKA) and PKG.{62567}
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