2-Chloroadenosine 5-triphosphate (sodium salt), CAS 301334-89-4

Formulation: A solution in water

Formal Name: 2-chloro-adenosine 5′-(tetrahydrogen triphosphate), tetrasodium salt

Purity: ≥95%

Formula Markup: C10H11ClN5O13P3 • 4Na

Formula Weight: 629,6

Shelf life (days): 730

CAS Number: 301334-89-4

Notes: 2-Chloroadenosine 5-triphosphate (2-chloro ATP) is an adenine nucleotide and analog of ATP (Item No. 14498).{62566,62567} It is an antagonist of the purinergic P2Y1 receptor, inhibiting intracellular calcium mobilization induced by ADP (Item No. 21121) in Jurkat cells expressing the human receptor (Ki = 2.3 µM).{62568} 2-chloro ATP is an agonist of purinergic P2X receptors, inducing inward currents in HEK293 cells expressing the human bladder smooth muscle or rat PC12 forms of the receptor (EC50s = 0.5 and 2.5 µM, respectively).{62569} It induces relaxation of precontracted isolated guinea pig taenia caeci strips in a concentration-dependent manner.{62566} It has been used to study the substrate specificity of cyclic nucleotide-dependent protein kinases, such as protein kinase A (PKA) and PKG.{62567}

• SKU: CAY34978-2.7
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 34978-2.7
• Green Labware: No
• Package Unit: 2,7 mg
• Quantity Unit: STK