Formulation: A solution in water
Formal Name: 2-(methylthio)-adenosine 5'-(trihydrogen diphosphate), trisodium salt
Purity: ≥98%
Formula Markup: C11H14N5O10P2S • 3Na
Formula Weight: 539,2
Shelf life (days): 730
CAS Number: 475193-31-8
Notes: 2-Methylthioadenosine diphosphate (2-MeSADP) is an agonist of purinergic P2Y receptors with EC50s of 5.13 and 0.89 nM for human recombinant P2Y1 and P2Y12 receptors, respectively.{43571} It also acts as an agonist at rat P2Y1 and P2Y12 and mouse P2Y13 receptors (EC50s = 0.58, 0.89, and 6.2 nM, respectively).{43571,43572} It induces platelet aggregation and inhibits cyclic AMP accumulation in platelet-rich plasma stimulated by prostaglandin E1 (PGE1; Item No. 13010) more potently than ADP (Item Nos. 21121 / 16778).{43573}