Formulation: A solid
Formal Name: α,3,4-trihydroxy-benzeneacetic acid
Purity: ≥95%
Formula Markup: C8H8O5
Formula Weight: 184,1
Shelf life (days): 1460
CAS Number: 775-01-9
Notes: 3,4-Dihydroxymandelic acid is an active metabolite of the endogenous catecholamine (–)-norepinephrine (Item No. 16673).{66349} It is formed from (–)-norepinephrine via the intermediate norepinephrine aldehyde by aldehyde dehydrogenase. 3,4-Dihydroxymandelic acid scavenges superoxide radicals (IC50 = 130 nM) and reduces lipid peroxidation in cell-free assays.{66350} 3,4-Dihydroxymandelic acid is also formed from norepinephrine by gut microbiota, such as E. coli.{66351} It is a chemoattractant for enterohemorrhagic E. coli that induces the expression of virulence genes when used at a concentration of 50 µM and increases the attachment of enterohemorrhagic E. coli to HeLa cells in vitro.
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