Formulation: A crystalline solid
Formal Name: 3,4-dihydroxy-benzeneacetic acid
Purity: ≥98%
Formula Markup: C8H8O4
Formula Weight: 168,1
Shelf life (days): 1460
CAS Number: 102-32-9
Notes: 3,4-dihydroxyphenylacetic acid (DOPAC) is a metabolite of dopamine (Item No. 21992) formed through deamination by monoamine oxidase (MAO).{36669} DOPAC is further metabolized by catechol-O-methyltransferase (COMT) to form homovanillic acid, and DOPAC levels are increased 5- to 6-fold compared to wild-type in the nucleus accumbens, striatum, and prefrontal cortex of COMT knockout mice. DOPAC oxidation is catalyzed by α-synuclein and oxidized DOPAC binds to monomeric α-synuclein preventing fibrillation.{36668} In vivo, foot shock stress increases DOPAC levels relative to control by approximately 45% in the prefrontal cortex and by 15% in the olfactory tubercles and ventral tegmental area (VTA) in rats.{36667}
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