Formulation: A solid
Formal Name: 3-hydroxy-benzeneacetic acid
Purity: ≥98%
Formula Markup: C8H8O3
Formula Weight: 152,1
Shelf life (days): 1460
CAS Number: 621-37-4
Notes: 3-Hydroxyphenylacetic acid is a phenolic acid with diverse biological activities.{68067,68066,68065,68064} It is formed via microbial metabolism of polyphenolic compounds, including the flavonoid quercetin (Item No. 10005169), by gut microbiota.{46257} 3-Hydroxyphenylacetic acid binds to the γ-hydroxybutyrate receptor (GHBR; IC50 = 12 µM) and GABAA receptors in rat cerebrocortical membranes.{68067} It increases the activity of aldehyde dehydrogenase (ALDH) in Hepa-1c1c7 and HepG2 cells and protects Hepa-1c1c7 cells from acetaldehyde-induced cytotoxicity when used at a concentration of 10 µM.{68066} 3-Hydroxyphenylacetic acid is active against P. aeruginosa (MIC = 2.1 mg/ml).{68065} It induces ataxia and decreases locomotor activity in mice (ED50s = 1,677.3 and 1,441.3 mg/kg, respectively), as well as decreases systolic and diastolic blood pressure in spontaneously hypertensive rats when administered at doses ranging from 0.1 to 10 mg/kg.{68067,68064}
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