Formulation: A solution in methanol
Formal Name: 2,2,3-trimethyl-cyclopentanebutanoic acid
Purity: ≥98%
Formula Markup: C12H22O2
Formula Weight: 198,3
Shelf life (days): 730
CAS Number: 957136-80-0
Notes: 4-(2,2,3-Trimethylcyclopentyl)butanoic acid is an orthosteric, insurmountable antagonist of the human bitter taste receptors hTAS2R31 and hTAS2R43.{32346} It prevents the activation of hTAS2R31 by saccharin and acesulfame K in cells with IC50 values of 7.9 and 2.4 µM, respectively.{32346} In human sensory trials, 4-(2,2,3-trimethylcyclopentyl)butanoic acid significantly reduced the bitter flavor associated with these two artificial sweeteners.{32346}