Formulation: A solid
Formal Name: 4-methyl-1H-imidazole-5-ethanamine, dihydrochloride
Purity: ≥95%
Formula Markup: C6H11N3 • 2HCl
Formula Weight: 198,1
Shelf life (days): 1460
CAS Number: 36376-47-3
Notes: 4-Methylhistamine is a histamine H4 receptor agonist (Ki = 50 nM).{36324} It is >100-fold selective for H4 over other histamine receptors. 4-Methylhistamine inhibits CRE-β-galactosidase activity induced by forskolin (Item No. 11018) with an EC50 value of 39.8 nM in SK-N-MC cells transfected with the human H4 receptor. It induces a change in eosinophil shape (EC50 = 0.36 μM) and stimulates migration of murine bone marrow mast cells (EC50 = 12 μM), activities that can be inhibited by the histamine H4 antagonist JNJ-7777120 (Item No. 10011925). Intratracheal administration of 4-methylhistamine (10 μg/animal) reduces airway resistance and inflammation and increases the number of CD4+CD25+FoxP3+ regulatory T cells in a mouse model of allergic asthma.{36323} 4-Methylhistamine also reduces epidermal hyperplasis, hyperkeratosis, and lymphocyte infiltration and increases the number of CD4+CD25+FoxP3+ regulatory T cells in a mouse model of psoriasis induced by imiquimod (Item No. 14956).{36325}
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