Formulation: A crystalline solid
Formal Name: 5,7-dichloro-4-hydroxy-2-quinolinecarboxylic acid
Purity: ≥98%
Formula Markup: C10H5Cl2NO3
Formula Weight: 258,1
Shelf life (days): 1460
CAS Number: 131123-76-7
Notes: 5,7-Dichlorokyneurenic acid (5,7-DCKA) is a derivative of kynurenic acid (Item No. 16792) and an NMDA receptor antagonist (Ki = 40 nM in a radioligand binding assay).{41941} It selectively inhibits glycine- over kainate-induced NMDA currents at 15 μM in Xenopus oocytes expressing rat NMDA receptors. 5,7-DCKA reduces NMDA-induced neurotoxicity in primary rat cortical neurons by 55 to 90% when used at concentrations ranging from 1 to 10 μM. In vivo, 5,7-DCKA (0.97-97 nmol) reverses mechanical hyperalgesia in magnesium-deficient rats in a dose-dependent manner.{41942} It blocks the positive ionotropic effect, hypertension, and increase in myocardial oxygen demand induced by electrical stimulation of the paraventricular nucleus (PVN) in anesthetized rabbits.{41943} 5,7-DCKA also increases social interaction time in the social interaction test and time spent in the open arms of the elevated plus maze, indicating anxiolytic-like activity, as well as disinhibits conflict responding in the Cook and Davidson conditioned conflict paradigm.{41944}
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